TABLE 2

Amount of Insulin Received, Plasma Insulin and IGF-1 Concentrations, Blood Glucose Concentrations, and Incidence of Glycosuria in Randomly Assigned Infants

Tight GroupControl GroupP Value
n4345
Treated with insulin42 (98)29 (64)<.0001
Total insulin dose, U/kg13.5 (4.0–30.0)1.8 (0–9.7)<.0001
Daily mean dose of insulin,a U/kg/hr0.06 (0.05–0.07)0.04 (0.04–0.05).002
Time on insulin, h168 (80–413)44 (0–179)<.0005
Plasma insulin, µU/mL.43
D after randomization
 118.7 (10.8–27.9)25.2 (12.8–37.8)
 716.9 (9.4–26.4)12 (7.0–22.4)
 148.1 (3.1–13.6)10.3 (5.2–26.5)
36 wk postmenstrual age5.9 (2.7–10.6)5.7 (1.5–10.5)
Plasma IGF-1, ng/mL.97
D after randomization
 13.4 (2.1–6.4)5.7 (2.6–7.8)
 75.8 (3.9–8.1)5.8 (3.7–7.3)
 148.1 (4.2–10.6)7.8 (4.2–12.5)
36 wk postmenstrual age18.4 (11.1–24.8)18.1 (14.6–22.7)
BGC, all measurements, mmol/L
 Daily maximum6.5 (5.2–8.4)6.9 (5.2–9.5)<.0005
 Daily mean5.7 (4.8–6.7)6.5 (5.1–8.2)<.0001
 Daily minimum4.7 (3.7–5.9)5.7 (4.7–7.1)<.0001
BGC, while receiving insulin, mmol/L
 Daily maximum7.7 (6.3–9.6)10.8 (9.3–12.7)<.0001
 Daily mean5.8 (5.1–7.1)8.5 (7.5–10)<.0001
 Daily minimum4.2 (3.4–5.3)6.5 (5.1–7.8)<.0001
Blood glucose measurements, n80 (49–139)46 (31–94).03
Infants with glycosuria >2+, n12 (28)21 (47).07
Days with glycosuria >2+0.0 (0.0–1.0)0.0 (0.0–2.5).04
Urinalysis measurements after randomization, n12 (8–25)13 (7–26).98
  • Data are median (interquartile range) or number (%).

  • a Infants who received insulin.