TABLE 3

Growth Parameters at 36 weeks’ PMA, z Score Change From Birth to 36 weeks’ PMA, and Clinical Outcomes for Randomly Assigned Infants

Tight GroupControl GroupP ValueAdjusted P Valuea
Growth parametersn = 38n = 43
 Lower-leg length, mm108.8 ± 1.2110.6 ± 1.0.25.43
 Weight
  grams2196 ± 652265 ± 59.44.66
  z score−1.40 ± 0.16−1.22 ± 0.15.44.65
  z score changeb−1.08 ± 0.12−1.34 ± 0.16.19.41
 Head circumference
  cm30.7 ± 0.330.9 ± 0.2.55.81
  z score−1.7 ± 0.20−1.60 ± 0.15.63.75
  z score changeb−1.40 ± 0.22−1.90 ± 0.14.06<.05
 Length
  cm42.8 ± 0.443.3 ± 0.4.41.85
  z score−2.07 ± 0.17−1.91 ± 0.14.47.91
  z score changeb−1.68 ± 0.13−1.82 ± 0.13.45.56
Clinical outcomesn =43n = 45
 Death
  Before day 284 (9)1 (2).14.20
  Before 36 wk PMA5 (12)2 (4).21.31
  Before discharge5 (12)4 (9).67.94
 Sepsis19 (44)14 (31).21.28
 NEC (Bell stage ≥2)2 (5)1 (2).53.67
 IVH (grade III or IV)6 (14)3 (7).23.35
 Periventricular leukomalacia1 (2)2 (4).64.57
 Blood transfusions6 (3–8)5 (2–7).36NAc
 Hypoglycemiad
  No. of infantse
   <2.6 mmol/L25 (58)12 (27)<.005<.01
   <1.5 mmol/L7 (16)2 (4).06.11
  No. of episodes
   <2.6 mmol/L1 (0–2)0 (0–1)<.005NAc
   <1.5 mmol/L0 (0–0)0 (0–0).08NAc
 Recurrent hypoglycemiaf7 (16)2 (4).06.11
 ROP treatment9 (21)4 (9).11.20
 Patent ductus arteriosus22 (51)30 (67).14.11
 Days on mechanical ventilation6 (3–22)9 (2–21).77NAc
 Chronic lung disease18 (42)20 (44).90.40
 Postnatal steroids12 (28)17 (38).41.28
 Days to full enteral feeds14 (11–20)14 (11–16).75NAc
 Days to discharge103 (5)96 (4).30.89
  • Data are mean ± SEM, median (interquartile range) or number (%). IVH, intraventricular hemorrhage; ROP, retinopathy of prematurity; NEC, necrotizing enterocolitis.

  • a Adjusted for birth weight.

  • b z score change represents the z score at 36 weeks’ PMA – z score at birth.

  • c Not available (nonparametric data not adjusted).

  • d After randomization.

  • e With 1 or more episodes of hypoglycemia.

  • f BGC of <2.6 mmol/L on 3 or more days.