TABLE 2

Change in Pain Score (VAS) From Baseline and Number of Patients Who Achieved Adequate Analgesia

OutcomeCodeineAcetaminophenIbuprofenP
NaMean or n (%)95% CLNMean or n (%)95% CLNMean or n (%)95% CL
Change in VAS from baseline
    30 min105−10−14, −6103−7−12, −3103−12−16, −9.230
    60 min100−11−16, −5100−12−16, −8100−24−29, −20<.001
    90 min85−13−20, −688−17−23, −1290−29−34, −23.001
    120 min75−17−25, −979−20−25, −1483−31−37, −26.004
VAS <30 mmb
    60 min10040 (40)31, 5010036 (36)27, 4610052 (52)42, 62<.001
    120 min7539 (52)41, 637927 (47)36, 588351 (61)42, 62.170
  • Posthoc test significance (Tukey): VAS at 60 minutes: acetaminophen versus codeine (P = .98), acetaminophen versus ibuprofen (P = .001), codeine versus ibuprofen (P < .001); VAS at 90 minutes: acetaminophen versus codeine (P = .55), acetaminophen versus ibuprofen (P = .016), codeine versus ibuprofen (P = .001); VAS at 120 minutes: acetaminophen versus codeine (P = .85), acetaminophen versus ibuprofen (P = .026), codeine versus ibuprofen (P = .006); VAS <30 mm at 60 minutes: acetaminophen versus codeine (P = .85), acetaminophen versus ibuprofen (P = .026), codeine versus ibuprofen (P = .006). CL indicates confidence limit. Adequate analgesia was defined as a VAS <30 mm.

  • a The number of patients at each time decreased because patients were discharged home from the ED and did not return pain scores for later time periods.

  • b Because we have no data on patients who did not complete the VAS at home after discharge, these data represent cross-sectional data on those patients on whom VAS scores were available.