TABLE 3

AEs Grouped According to Study Design

AuthorsTreatment Arm, No. of AEs/No. of Patients (%)aControl Arm, No. of AEs/No. of Patients (%)aTotal No. of AEs/No. of Patients (%)a
RCTs
    Needle acupuncture in both arms
        Shenkman et al45 (1999)10/47 (21.2)8/53 (15.1)18/100 (18.0)
        Ng et al46 (2004)5/32 (15.6)4/31 (12.9)9/63 (14.3)
        Wong et al52 (2010)30/30 (100.0)NR/25 (—)30/30 (100.0)
        Total45/109 (41.3)12/84 (14.2)57/193 (29.5)
    Needle acupuncture compared to acupressure
        Sun et al47 (2004)4/22 (18.2)2/11 (18.2)6/33 (18.2)
        Wong and Sun51 (2010)25/25 (100.0)NR/25 (—)25/25 (100.0)
        Total29/47 (61.7)2/11 (18.2)31/58 (53.4)
    Needle acupuncture compared to other conventional treatment
        Reindl et al48 (2006)1/11 (9.1)0/11 (0.0)1/22 (4.5)
        Gottschling et al49 (2008)4/23 (17.4)0/23 (0.0)4/46 (8.7)
        Leung et al50 (2009)2/15 (13.3)0/20 (0.0)2/35 (5.7)
        Total7/49 (14.3)0/54 (0.0)7/103 (6.8)
    RCTs total81/205 (39.5)14/149 (9.4)95/354 (26.8)
Single-arm cohort studies
    Wong et al55 (2001)3/10 (33.3)NA3/10 (33.3)
    Endres et al56 (2004)64/1109 (5.8)NA64/1109 (5.8)
    Wong et al57 (2006)4/12 (33.3)NA4/12 (33.3)
    Chen et al58 (2008)4/2 (200.0)NA4/2 (200.0)
    Cohort total75/1133 (6.6)NA75/1133 (6.6)
Total156/1338 (11.7)14/149 (9.4)170/1487 (11.4)
  • NR indicates not reported; —, could not be calculated; NA, not applicable.

  • a AEs were reported at least once per patient.