TABLE 4

Demographic Factors, Chronic Health Conditions, Clinical Conditions, and Secondary Infections Associated With Mortality in 838 Children Admitted to a PICU With pH1N1

Parametern (%)RR Death (95% CI)P
Univariate analysis
    Female gender353 (42.1)2.0 (1.3–3.0).002
    Age 5–20 y (vs 0–4 y)523 (62.4)1.5 (1.0–2.5).07
    Neurologic/neuromuscular condition263 (31.4)1.9 (1.2–2.9).003
    Immune compromise33 (3.9)2.5 (1.3–5.0).01
        Active hematologic malignancy9 (1.1)3.8 (1.5–9.9).04
    Metabolic disorder37 (4.4)2.2 (1.1–4.5).03
    Encephalitis diagnosed14 (1.7)3.3 (1.4–7.8).03
    Myocarditis diagnosed6 (0.7)3.8 (1.2–12.0).09
    Bacterial pneumonia/coinfectiona274 (32.7)1.8 (1.2–2.8).007
        Pathogen identified in respiratory secretions
             Within ≤72 h of PICU admissionb183 (21.8)1.7 (0.8–3.5).2
        S aureus (lung) within ≤72 h71 (8.5)2.3 (1.3–3.9).004
             MSSA (lung) within ≤72 h37 (4.4)1.2 (0.5–3.2)NS
             MRSA (lung) within ≤72 h34 (4.1)3.2 (1.8–5.9).0003
Multivariate analysisc
    Female gender353 (42.1)1.9 (1.2–3.0).003
    Neurologic condition263 (31.4)1.8 (1.1–2.7).01
    Immune compromise33 (3.9)2.2 (1.1–4.5).02
    Encephalitis diagnosed14 (1.7)3.4 (1.6–7.5).002
    Myocarditis diagnosed6 (0.7)3.8 (1.2–12.0).03
    Presumed MRSA lung coinfection within ≤72 h34 (4.1)3.3 (1.7–6.4).0005
  • NS indicates not significant; MSSA, methicillin-susceptible S aureus.

  • a Clinical diagnosis of bacterial pneumonia or superinfection at any time during PICU stay.

  • b When the comparison group is not specified, patients with the factor were compared to patients without the factor for those patients for whom the factor was reported.

  • c The results for all factors tested in the multivariate analysis are reported in Supplemental Table 9.