Evidence Grading System: Quality Grades

AWell-designed RCTs or diagnostic studies performed on a population similar to the guideline's target population
BRCTs or diagnostic studies with minor limitations; genetic natural history studies; overwhelmingly consistent evidence from observational studies
CObservational studies (case-control and cohort design)
DExpert opinion, case reports, or reasoning from first principles (bench research or animal studies)
  • Adapted from American Academy of Pediatrics, Steering Committee on Quality Improvement and Management. Pediatrics. 2004;114(3):874–877.