TABLE 3

Impact of Childhood Immunization at 1 Year of Age Compared With No Vaccination in 2 US Regions and Compared Nationally With No Vaccination

OutcomesACIP Region
Regions 1 and 2aRegion 3bAll Regions
Reduction in disease events, n
    Infections135 48636 848172 334
    Deaths221032
    LYs savedc17870247
    QALYs savedd16405142154
Reduction in medical services, n
    Outpatient visits116 52236 847153 369
    Hospitalizations19967032699
    Liver transplants14620
Change in costs, $
    Total healthcare costs12 800 00073 500 00086 300 000
        Vaccination46 300 00084 200 000130 500,000
        Hepatitis A medical costs(29 300 000)(9400,000)(38 700 000)
        Public health costs(4200,000)(1300,000)(5500,000)
    Total productivity costs(28 400 000)(8600,000)(37 000 000)
    Total costs for cost per LY savedc(16 000 000)65 300 00049 300 000
    Total costs for cost per QALY savedd(7300,000)68 200 00060 900 000
    Cost per LY savedcCost-saving933 000199 000
    Cost per QALY saveddCost-saving133 00028 000
  • a Regions 1 and 2 include 11 states for which the ACIP recommended hepatitis A vaccination and 6 states for which the ACIP called for consideration of vaccination.

  • b Region 3 includes 33 states and the District of Columbia, for which the ACIP made no recommendation regarding hepatitis A immunization.

  • c Cost per LY saved is equal to discounted total costs for cost per LY saved divided by discounted LYs saved.

  • d Cost per QALY saved is equal to discounted total costs for cost per QALY saved divided by discounted QALYs saved.