TABLE 2

Expected Hepatitis A Disease Outcomes and Costs with No Immunization

VariableACIP Region
Regions 1 and 2aRegion 3bAll Regions
Outcomes
    No. of disease events
        Symptomatic anicteric50 23912 23062 469
        Icteric (acute hepatitis A)55 31818 49373 812
        FLF16062222
        Deaths602282
        LYs lost from hepatitis Ac268101369
        QALYs lost from hepatitis Ac19596192577
    No. of medical services
        Outpatient visits143 18945 587188 775
        Hospitalizations26089103518
        Liver transplants23933
Costs
    Total costs for cost per LY saved, $76 500 00035 900 000112 400 000
    Total costs for cost per QALY saved, $d90 200 00043 300 000133 500 000
  • a Regions 1 and 2 include 11 states for which the ACIP recommended hepatitis A vaccination and 6 states for which the ACIP called for consideration of vaccination.

  • b Region 3 includes 33 states and the District of Columbia, for which the ACIP made no recommendation regarding hepatitis A immunization.

  • c Discounted to 2005 value.

  • d Excludes productivity losses other than those associated with caregivers of infected children.