TABLE 7

Neurodevelopmental Outcomes According to Pathogen Groups for Infants With Proven Sepsis Compared With Uninfected Infants

OutcomeInfectionUnivariableaMultivariablea,b
Infected, n (%)Uninfected, n (%)OR (95% CI)POR (95% CI)P
Gram-positive sepsis (N = 112)
    Cerebral palsy13 of 112 (12)10 of 236 (4)3.47 (1.43–8.42).0064.05 (1.48–11.07).006
    NDI37 of 110 (34)55 of 235 (23)1.76 (1.03–3.02).0401.71 (0.95–3.09).074
Coagulase-negative staphylococci (N = 77)
    Cerebral palsy10 of 77 (13)10/236 (4)4.46 (1.69–11.72).0025.59 (1.87–16.66).002
    NDI24 of 75 (32)55 of 235 (23)1.59 (0.87–2.93).1341.58 (0.82–3.04).173
Other Gram-positive bacteria (n = 43)
    Cerebral palsy4 of 43 (9)10 of 236 (4)2.70 (0.76–9.57).1252.43 (0.47–12.78).291
    NDI16 of 43 (37)55 of 235 (23)2.04 (0.98–4.25).0561.81 (0.80–4.07).157
Gram-negative sepsis (N = 29)
    Cerebral palsy1 of 29 (3)10 of 236 (4)0.73 (0.08–6.23).7700.44 (0.03–5.60).529
    NDI11 of 29 (38)55 of 235 (23)2.04 (0.89–4.70).0941.50 (0.55–4.04).427
  • a Results of binary logistic regression.

  • b Including center, year of birth, gender, gestational age, birth weight, brain injury, BPD, ROP, socioeconomic status, and postnatal growth as covariables.