TABLE 4

Association of Clinical and Demographic Parameters With Neurodevelopmental Outcomes in Infants With Proven Sepsis Compared With Uninfected Infants

Univariable ModelaMultivariable Modelb
OR (95% CI)POR (95% CI)P
Cerebral palsy
    Proven sepsis2.90 (1.22–6.89).0163.23 (1.23–8.48).017
    Gender0.74 (0.31–1.72).4800.68 (0.25–1.84).449
    Gestational age0.90 (0.33–2.42).8350.83 (0.26–2.66).755
    Birth weight0.90 (0.54–1.50).6881.26 (0.65–2.44).493
    Prenatal steroids0.70 (0.29–1.68).429NA
    Persistent ductus arteriosus0.93 (0.40–2.16).863NA
    BPD1.93 (0.78–4.77).1551.44 (0.52–4.00).480
    Brain injury8.21 (2.84–23.8)<.0018.80 (2.57–30.1).001
    ROP0.95 (0.12–7.72).9591.36 (0.14–12.8).790
    Socioeconomic status, middle class1.26 (0.48–3.31).6391.66 (0.56–4.89).632
    Socioeconomic status, lower class1.23 (0.35–4.37).7522.28 (0.57e9.08).243
    Postnatal growth0.85 (0.60–1.19).3360.79 (0.54–1.17).246
NDI
    Proven sepsis1.85 (1.12–3.05).0161.69 (0.96–2.98).067
    Gender1.43 (0.88–2.32).1541.49 (0.86–2.61).158
    Gestational age0.63 (0.37–1.09).0960.84 (0.43–1.67).624
    Birth weight0.78 (0.58–1.06).1111.00 (0.68–1.47).995
    Prenatal steroids0.92 (0.55–1.54).744NA
    Persistent ductus arteriosus1.13 (0.69–1.84).628NA
    BPD3.02 (1.75–5.23)<.0011.98 (1.07–3.68).029
    Brain injury2.64 (1.10–6.32).0303.45 (1.31–9.09).012
    ROP4.56 (1.55–13.4).0065.86 (1.70–20.2).005
    Socioeconomic status, middle class1.50 (0.85–2.66).1601.72 (0.91–3.25).092
    Socioeconomic status, lower class1.75 (0.87–3.53).1162.54 (1.17–5.53).019
    Postnatal growth0.82 (0.68–1.00).0500.86 (0.68–1.08).203
  • a Given are all parameters that showed an unequal distribution among groups as shown in Table 2 or that are known from previous publications to act as confounders. The univariable model is adjusted for study center and study year.

  • b The multivariable model contains all parameters that were associated with the outcome in the univariable model plus demographic factors such as gender and birth weight.