TABLE 5

Neurodevelopmental Outcomes for Infants With Proven Sepsis and for Infants With Suspected Sepsis Compared With Uninfected Infants

OutcomeType of Infection, SepsisUnivariableaMultivariablea,b
Proven or Suspected, n (%)Uninfected, n (%)OR (95% CI)POR (95% CI)P
Proven Sepsis (N = 136)
    Cerebral palsy14 of 136 (10)c10 of 236 (4)2.90 (1.22–6.89).0163.23 (1.23–8.48).017
    NDI46 of 134 (34)c55 of 235 (23)1.85 (1.12–3.05).0161.69 (0.96–2.98).067
    PDI < 7032 of 128 (25)c29 of 193 (15)2.10 (1.15–3.81).0151.80 (0.95–3.41).073
    MDI < 7030 of 132 (23)c39 of 229 (17)1.47 (0.84–2.56).1741.37 (0.73–2.58).325
    MDI or PDI scores between 70 and 8443 of 134 (32)c68 of 232 (29)1.12 (0.70–1.79).6400.96 (0.57–1.59).863
Suspected sepsis (N = 169)
    Cerebral palsy17 of 169 (10)d10 of 236 (4)2.55 (1.10–5.93).0301.79 (0.61–5.25).287
    NDI50 of 167 (30)d55 of 235 (23)1.40 (0.86–2.25).1730.99 (0.57–1.73).980
    PDI < 7038 of 164 (23)d29 of 193 (15)1.71 (0.97–3.00).0631.36 (0.72–2.59).341
    MDI < 7030 of 166 (18)d39 of 229 (17)1.13 (0.65–1.96).6590.70 (0.36–1.35).286
    MDI or PDI scores between 70 and 8449 of 167 (29)d68 of 232 (29)1.05 (0.67–1.65).8321.23 (0.75–2.01).419
  • a Results of binary logistic regression.

  • b Including center, year of birth, gender, gestational age, birth weight, brain injury, BPD, ROP, socioeconomic status, and postnatal growth as covariables.

  • c Proven sepsis.

  • d Suspected sepsis.