TABLE 5

Frequency of Unique AEs

RankAEUnique AEs%
1Nosocomial infection (sepsis, wound, etc)15427.8
2Catheter infiltration/burn8615.5
3Abnormal cranial imaging5810.5
4Unplanned extubation requiring reintubation468.3
5Hypotension427.6
6Necrotizing enterocolitis295.2
7Seizures285.1
8Death274.9
9Acute renal failure142.5
10Respiratory arrest132.3
11Hyperglycemia91.6
12Electrolyte abnormality71.3
13Catheter malpositioned/tip avulseda71.3
14Thrombus/embolus61.1
15Arrhythmias/cardiovascular compromisea61.1
16Neurologic findings (eg, encephalopathy)a20.4
17Skin damage (eg, nasal septum from CPAP)a20.4
18Chylothorax due to PDA ligationa20.4
19Return to surgery10.2
20Othera,b152.7
  • CPAP indicates continuous positive airway pressure; PDA, patent ductus arteriosus.

  • a AEs identified without a trigger (n = 34).

  • b “Other” included: acidosis, bowel resection, esophageal perforation by nasogastric tube, patient fed wrong breast milk, fracture, elevated direct bilirubin, ostomy prolapse, scalp avulsion, total parenteral nutrition precipitate, aspiration, postoperative bleeding, ineffective vascular access required surgical access, missed diagnosis, unplanned chest tube removal requiring replacement, and toe laceration.