TABLE 3

Characteristics of Patients With ADRs, According to Severity Level

Low SeverityHigh SeverityP
Agen = 897n = 112
    Mean ± SD, y7.0 ± 6.26.6 ± 5.5.555
     <1 mo, n (%)83 (9)7 (6).293
    1 to <12 mo, n (%)160 (18)13 (12).099
    1 to <5 y, n (%)177 (20)21 (19).805
    5 to <10 y, n (%)170 (19)25 (22).395
    10 to <15 y, n (%)158 (18)22 (20).597
    ≥15 y, n (%)149 (17)24 (21).202
Gendern = 896n = 112
    Male, n (%)470 (52)55 (49).504
Admitting diagnosis, n (%)n = 964n = 119
    Infectious diseases/fever202 (21)8 (7)<.001
    Hematologic malignancies153 (16)17 (14).654
    Prematurity107 (11)7 (6).080
    Solid tumors85 (9)5 (4).085
    Hematologic disorders50 (5)8 (7).483
    Seizures42 (4)8 (7).246
    Respiratory distress/apnea42 (4)7 (6).450
Location during reaction, n (%)n = 964n = 119
    General pediatrics344 (36)23 (19)<.001
    Hematology/oncology303 (31)41 (34).504
    PICU182 (19)25 (21).577
    NICU130 (14)8 (7).037
    Preadmission1 (0.1)26 (22)<.001
    Surgery05 (4)<.001
    Emergency department1 (0.1)01.000
History of drug allergies, n (%)n = 964n = 119
    No known drug allergies452 (47)46 (39).089
    Penicillins73 (8)4 (3).127
    Sulfa drugs14 (2)2 (2).693
No. of drug allergies, n (%)n = 964n = 119
    196 (10)9 (8).405
    227 (3)3 (3).861
    ≥313 (1)0.382
Length of hospitalizationn = 964n = 119.593
    Mean, d26.724.7
  • ADRs with low severity were assigned levels 1 to 3 and those with high severity levels 4 to 6.