APPENDIX 7

Diagnostic Accuracy of Screening Tests Stratified According to Age

Study (Year)Screening TestSensitivity (95% CI)Specificity (95% CI)PLR (95% CI)NLR (95% CI)Positive Predictive Value (95% CI)Negative Predictive Value (95% CI)Diagnostic OR (95% CI)
Chui et al33 (2004)Lea symbols visual acuity test, Frisby stereoacuity test, and external visual inspection0.67 (0.41–0.87); <41 mo: 0.75 (0.43–0.94); ≥41 mo: 0.50 (0.12–0.88)Overall: 0.86 (0.79–0.92); <41 mo: 0.90 (0.52–0.82); ≥41 mo: 0.95 (0.88–0.99)Overall: 4.8 (2.8–8.4); <41 mo: 2.4 (1.4–4.1); ≥41 mo: 10 (3.0–36)Overall: 0.39 (0.20–0.75); <41 mo: 0.37 (0.13–1.0); >41 mo: 0.53 (0.24–1.2)Overall: 0.41 (0.24–0.61); <41 mo: 0.41 (0.21–0.64); ≥41 mo: 0.43 (0.10–0.82)Overall: 0.95 (0.89–0.98); <41 mo: 0.90 (0.74–0.98); ≥41 mo: 0.96 (0.90–0.99)Overall: 12 (3.6–45); <41 mo: 6.5 (1.3–42); ≥41 mo: 20 (1.8–180)
Kemper et al41 (2005)SureSight autorefractorOverall: 0.85 (0.69–0.95); <3 y old (n = 80): 0.80 (0.44–0.97); 3–5 y old (n = 90): 0.88 (0.68–0.97)Overall: 0.52 (0.40–0.63); <3 y old: 0.41 (0.24–0.61); 3–5 y old: 0.58 (0.42–0.71)Overall: 1.8a; <3 y old: 1.4a; 3–5 y old: 2.1aOverall: 0.29a; <3 y old: 0.49a; 3–5 y old: 0.21aNot calculableNot calculableOverall: 6.2a; <3 y old: 2.9a; 3–5 y old: 10a
Kennedy and Thomas44 (2000)iScreen photoscreenerOverall: 0.92 (0.88–0.95); ≤3 y 1.0a; 4–6 y 0.92aOverall: 0.89 (0.83–0.94); ≤3 y 0.97a; 4–6 y 0.95aOverall: 8.6 (5.4–14); ≤3 y 33a; 4–6 y 18aOverall: 0.09 (0.06–0.13); ≤3 y not calculable; 4–6 y 0.08aOverall: 0.94 (0.90–0.96); ≤3 y 0.97a; 4–6 y 0.97aOverall: 0.86 (0.80–0.91)Overall: 100 (48–210); ≤3 y not calculable; 4–6 y: 220a
Tong et al56 (2000)MTI photoscreenerAll photographs: 0.56 (0.50–0.62); informative subset of 313 photographs: 0.65 (0.59–0.71)All photographs: 0.91 (0.84–0.96); informative subset of 313 photographs: 0.87 (0.76–0.94)All photographs: 6.4 (3.4–12); informative subset of 313 photographs: 4.9 (2.6–9.1)All photographs: 0.48 (0.42–0.56); informative subset of 313 photographs: 0.40 (0.33–0.47)All photographs: 0.95 (0.90–0.98); informative subset of 313 photographs: 0.95 (0.90–0.98)All photographs: 0.43 (0.36–0.50); informative subset of 313 photographs: 0.41 (0.33–0.49)All photographs: 13 (6.3–31); informative subset of 313 photographs: 12 (5.6–29)
  • a CIs not calculable.