TABLE 3

Association Between Cord-Blood 25(OH)D Levels (per 10 nmol/L Increase) and Risk of Wheeze Outcomes

OutcomeOR (95% CI)P
Wheeze by 15 mo of age (N = 331 cases)
    Unadjusted0.97 (0.94–1.01).13
    Multivariable model 10.96 (0.92–1.00).03
    Multivariable model 20.98 (0.93–1.02).30
Wheeze by 3 y of age (N = 472 cases)
    Unadjusted0.96 (0.92–0.99).001
    Multivariable model 10.94 (0.91–0.98).002
    Multivariable model 20.96 (0.91–1.00).04
Wheeze by 5 y of age (N = 533 cases)
    Unadjusted0.94 (0.91–0.97).001
    Multivariable model 10.93 (0.90–0.97)<.001
    Multivariable model 20.95 (0.91–0.99).02
Incident asthma by 5 y of age (N = 181 cases)
    Unadjusted0.98 (0.94–1.02).37
    Multivariable model 10.99 (0.94–1.04).76
    Multivariable model 21.03 (0.97–1.10).27
  • Model 1 adjusted for season of birth; model 2 adjusted for season of birth plus 13 potential confounders (study site, maternal age at birth, New Zealand Deprivation Index, maternal history of asthma, paternal history of asthma, gestational age, gender, child's ethnicity, any smoking during pregnancy, any passive smoke exposure at 3 months of age, number of children younger than 16 years in household at the time the child was 3 months old, endotoxin on bedroom floor at the time the child was 3 months old [in quartiles], and duration of exclusive breastfeeding).