TABLE 1

Perinatal and Postnatal Risk Factors in Newborns With and Without Moderate-Severe White Matter Injury

Clinical VariablesAbsent (n = 41)Present (n = 12)P
Perinatal
    Prenatal betamethasone21 (51)9 (75).2
    Chorioamnionitis9 (27)0.08
    Caesarian section delivery26 (63)8 (67).9
    Outborn delivery13 (32)4 (33).9
    Gestational age at birth, wk26 (24–27.7)26.8 (24.1–27.9).2
    Birth weight, g775 (485–1210)763 (563–1295).9
Postnatal
    Small for gestational age3 (7)1 (8).9
    Surfactant treatment34 (83)11 (92).7
    Chronic lung disease13 (34)3 (25).7
    Hypotension31 (78)10 (83).9
    Necrotizing enterocolitis8 (20)0.2
    Systemic infection23 (58)9 (75).3
    Mechanical ventilation, d29.5 (0–100)26.5 (0–47).2
    Intraventricular hemorrhage (any grade)15 (37)6 (50).5
    Ventriculomegaly7 (17)1 (8).7
    Hemodynamically significant PDA18 (44)1 (8).04
Indomethacin treatment
    Short course18 (44)11 (92).007
    Prolonged course23 (56)1 (8)
  • Data are n (%) or median (range).