TABLE 5.

Outcomes at 18 to 22 Months’ Corrected Age According to Head Circumference Growth Quartile

OutcomeaQuartile 1 (n = 124)Quartile 2 (n = 124)Quartile 3 (n = 123)Quartile 4 (n = 118)Pb
Rate of head circumference growth, mean (SD), cm/wk0.67 (0.17)0.87 (0.05)0.98 (0.06)1.17 (0.15)
Head circumference at status, cm30.9 (1.9)31.7 (1.2)31.6 (1.3)31.7 (1.5).0007
Normal neurologic examination, %64748289<.001
CP, %2217113<.001
MDI74.6 (18)76.7 (18)82.2 (16)80.9 (16)<.05
MDI <70, %44412322<.001
PDI72.0 (19)79.1 (19)84.1 (15)82.4 (14)<.001
PDI <70, %43291217<.001
Blind, %
    Unilateral2024.23
    Bilateral2130
Hearing impairment, %5633.47
Hearing aids, %4221.42
Neurodevelopmental impairment, %62513328<.001
Head circumference <10th percentile, %35182016<.01
  • a Missing data: head circumference growth, 1 infant; for quartiles 1 to 4, respectively: head circumference at status: 1, 1, 0, 0; CP: 2, 8, 3, 3 infants; neurologic examination: 3, 8, 4, 3; MDI scores: 12, 14, 14, 8; PDI scores: 12, 16, 19, 10; blindness: 3, 7, 3, 4; hearing impairment, hearing aids: 4, 8, 3, 4; NDI: 9, 16, 10, 11; head circumference <10th %: 3, 7, 5, 3.

  • b Kruskal-Wallis test for continuous variables; Mantel-Haenszel χ2 or Fisher’s exact test for categorical variables, as appropriate.