TABLE 5

Opsonophagocytic Activity Responses to the 7 Common Serotypes After the Toddler Dose

Immune MeasurementOPA Titer % ≥1:8aOPA GMTa
PCV13, OPA (95% CI)PCV7, OPA (95% CI)PCV13, OPA (95% CI)PCV7, OPA (95% CI)
Common serotypes
    498.9 (93.8–100)b98.9 (94.1–100)1180 (847–1643)c1492 (1114–1999)
    6B98.9 (94.1–100)100 (96.2–100)3100 (2337–4111)4066 (3243–5098)
    9V98.9 (94.0–100)100 (96.2–100)11856 (8810–15 955)18032 (14 125–23 021)
    14100 (96.1–100)100 (96.2–100)2002 (1453–2760)2366 (1871–2992)
    18C98.9 (94.0–100)100 (96.2–100)993 (754–1308)1722 (1327–2236)
    19F96.7 (90.8–99.3)94.8 (88.3–98.3)200 (144–276)167 (121–230)
    23F98.9 (94.0–100)100 (96.1–100)2723 (1961–3782)4982 (3886–6387)
Additional serotypes
    198.9 (93.9–100)12.0 (6.1–20.4)164 (114–237)5 (4–6)
    397.8 (92.3–99.7)43.8 (33.6–54.3)380 (300–482)12 (9–16)
    598.9 (94.0–100)5.2 (1.7–11.7)300 (229–393)5 (4–6)
    6A98.9 (94.1–100)94.8 (88.3–98.3)2242 (1707–2945)539 (375–774)
    7F100d (96.0–100)80.4d (70.9–88.0)11629 (9054–14 938)268 (164–436)
    19A97.8 (92.3–99.7)53.2 (42.6–63.6)1024 (774–1355)268 (164–436)
  • Opsonophagocytic activity responses before the toddler dose were not measured.

  • a Number of subjects with a determinate antibody titer for the specified serotype ranged from 88 to 96.

  • b Exact 2-sided CI is based on the observed proportion of subjects.

  • c CIs are back-transformations of a CI based on the Student's t distribution for the mean logarithm of the titers.

  • d 7F responder rate at ≥1:2048 is 93.4% (95% CI: 86.2–97.5) in PCV13 recipients and 23.9% (95% CI: 15.6–33.9) in PCV7 recipients.