TABLE 4

Pneumococcal Antipolysaccharide IgG GMCs (μg/mL) Before and After the Toddler Dose

Before Toddler DoseAfter Toddler DoseRatioc (95% CId)
PCV13, GMCa (95% CIb)PCV7, GMCa (95% CIb)PCV13, GMCa (95% CIb)PCV7, GMCa (95% CIb)
Common serotypes
    40.35 (0.31–0.39)0.51 (0.45–0.57)3.73 (3.28–4.24)5.49 (4.91–6.13)0.68 (0.57–0.80)
    6B0.78 (0.69–0.89)1.01 (0.88–1.15)11.53 (9.99–13.30)15.63 (13.80–17.69)0.74 (0.61–0.89)
    9V0.39 (0.35–0.43)0.53 (0.48–0.59)2.62 (2.34–2.94)3.63 (3.25–4.05)0.72 (0.62–0.85)
    141.89 (1.64–2.17)2.49 (2.17–2.85)9.11 (7.95–10.45)12.72 (11.22–14.41)0.72 (0.60–0.86)
    18C0.34 (0.30–0.37)0.45 (0.41–0.50)3.20 (2.82–3.64)4.70 (4.18–5.28)0.68 (0.57–0.81)
    19F0.73 (0.65–0.82)0.65 (0.57–0.74)6.60 (5.85–7.44)5.60 (4.87–6.43)1.18 (0.98–1.41)
    23F0.38 (0.33–0.44)0.48 (0.42–0.55)5.07 (4.41–5.83)7.84 (6.91–8.90)0.65 (0.54–0.78)
Additional serotypes
    10.64 (0.57–0.72)0.03 (0.02–0.03)5.06 (4.43–5.80)0.03 (0.03–0.03)86.48 (72.95–102.52)
    30.15 (0.13–0.17)0.05 (0.04–0.06)0.94 (0.83–1.05)0.07 (0.05–0.08)13.88 (11.42–16.87)
    50.77 (0.69–0.86)0.44 (0.37–0.51)3.72 (3.31–4.18)0.55 (0.47–0.64)6.76 (5.44–8.41)
    6A0.83 (0.75–0.92)0.30 (0.26–0.35)8.20 (7.30–9.20)1.87 (1.60–2.19)8.78 (7.15–10.78)
    7F0.83 (0.75–0.93)0.04 (0.04–0.05)5.67 (5.01–6.42)0.05 (0.04–0.05)69.30 (58.40–82.24)
    19A0.92 (0.81–1.05)0.70 (0.61–0.80)8.55 (7.64–9.56)3.54 (3.15–3.98)2.34 (2.01–2.72)
  • a GMCs were calculated by using all subjects with available data for the specified blood draw.

  • b CIs are back-transformations of a CI based on the Student's t distribution for the mean logarithm of the concentrations.

  • c Ratio of GMCs; PCV13/PCV7.

  • d CIs for the ratio are back-transformations of a CI based on the Student's t distribution for the mean difference of the logarithms of the measures (PCV13–PCV7 reference). Noninferiority was met if the lower limit of the 2-sided CI was >0.5.