TABLE 3

FEV1 (% predicted) in preterm survivors measured in early adulthood compared with controls

StudySubject CharacteristicsYear of BirthAge, Mean, yPreterm GroupsControls; nMean Difference (95% CI)
BPD, Mean (SD); nNo BPD, Mean (SD); nBPD vs no BPDBPD vs ControlsNo BPD vs Controls
Halvorsen et al23<29 wk gestation or BW < 1001 g, regional cohort1982–198517.787.8 (13.8); 12a97.7 (12.9); 34108.1 (13.8); 46−9.9 (−18.8 to −1.0)−20.3 (−29.3 to −11.3)−9.9 (−18.8 to −1.0)
Doyle et al24BW < 1501 g, single hospital1977–198218.981.6 (18.7); 33b92.9 (12.8); 11499.4 (9.5); 37−11.3 (−16.9 to −5.7)−17.8 (−24.8 to −10.8)−6.5 (−11.0 to −2.0)
Vrijlandt et al25<32 wk gestation or BW < 1500 g, 2 hospitals19831990.1 (19.8); 8c99.2 (17.9); 12109.6 (13.4); 48−9.1 (−27.0 to 8.8)−19.5 (−30.5 to −8.5)−10.4 (−19.7 to −1.1)
  • BW indicates birth weight.

  • a The BPD group had oxygen requirement at 36 weeks; the remainder in this table are considered to have no BPD, although 24 of those in the preterm group with no BPD were oxygen dependent at 28 days.

  • b BPD was determined by ventilator dependency, oxygen requirement for >28 days, and chest radiograph consistent with Northway stage 3 or 4 changes.60

  • c BPD was defined as need for oxygen at 28 days and chronic changes (not specified) on chest radiograph; data only for males in both preterm groups.