TABLE 12

Acid-Suppressive Medications for Use in Treatment of GERD in Children

MedicationDosageComments
Omeprazole (capsulesa and oral suspensiona)1–16 y of age: 5 to <10 kg, 5 mg/d; 10 to <20 kg, 10 mg/d; ≥20 kg, 20 mg/d; adult dosing: 20 mg/d for 4–8 wkAdverse events of respiratory system, fever (from adult studies: headache, abdominal pain, nausea, diarrhea); capsules can be administered with applesauce
Lansoprazole (tabletsa, capsulesa, and oral suspensiona)1–11 y of age: ≤30 kg, 15 mg/d for ≤12 wk; >30 kg, 30 mg/d for ≤12 wk; 12–17 y of age: 15–30 mg/d for ≤8 wk; adult dosing: 15–30 mg/d for ≤8 wkConstipation, headache, abdominal pain, nausea, dizziness (from adult studies: diarrhea, abdominal pain, nausea, constipation); strawberry-flavored SoluTabs do not need to be swallowed; capsules can be administered with apple, orange, or tomato juice
Pantoprazole (tabletsa and oral suspensiona)b; adult dosing: 40 mg/d for ≤8 wk(From adult studies: headache, diarrhea, flatulence, abdominal pain)
Rabeprazole (tabletsa)Adolescents ≥12 y of age: 20 mg/d for ≤8 wk; adult dosing: 20 mg/d for 4–8 wkHeadache, nausea (from adult studies: pain, pharyngitis, flatulence, constipation)
Esomeprazole (capsulesa and oral suspensiona)1–11 y of age: 10 or 20 mg/d for ≤8 wk; 12–17 y of age: 20–40 mg/d for ≤8 wk; adult dosing: 20 or 40 mg/d for 4–8 wkHeadache, diarrhea, abdominal pain, nausea, somnolence (from adult studies: headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth)
  • a Delayed-release formulations.

  • b Safety and efficacy of pantoprazole have not been established for the pediatric population.