APPENDIX 8

Recommendations for Compatibility of Antimicrobial Agents and Breastfeeding

Antimicrobial AgentUS National Library of Medicine LACTMEDaBriggs’ Pregnancy and Lactationb
AmoxicillinAcceptable to useCompatible
AmpicillinAcceptable to useCompatible
ChloramphenicolAlternate drug is preferredPotential toxicity
CiprofloxacinShort-termc use is acceptableLimited human data—potential toxicity
Clindamycin Not a reason to discontinue breastfeeding Alternate drug is preferredCompatible
DoxycyclineShort-term use is acceptable Avoid prolongedd or repeat coursesCompatible
ImipenemAcceptable to useLimited human data—probably compatible
LevofloxacinShort-termc use is acceptableLimited human data—probably compatible
LinezolidNot a reason to discontinue breastfeedingNo human data—potential toxicity
MeropenemNot expected to cause adverse effectNo human data—probably compatible
MoxifloxacinShort-termc use is acceptableNo human data—probably compatible
PenicillinAcceptable to useCompatible
RifampinNot expected to cause adverse effectsCompatible
  • a toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT.

  • b Briggs GG, Freeman RK, Yaffe SJ, eds. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.

  • c 7–14 days.

  • d More than 14 days.