TABLE 3.

Incidence Rates of Mucocutaneous Reactions Among Children With a Prescription of Any NSAID, Acetaminophen, or Nonopioid Analgesics According to Patient Characteristics and Concomitant Prescriptions of Other Drugs

Patient CharacteristicsSevere ReactionsMild Reactions
CasesIncidence Rate Per 100 000 Person-DaysRR95% CI of RRCasesIncidence Rate Per 1000 Person-DaysRR95% CI of RR
Gender
    Female189.30.80.4–1.56703.50.90.8–1.0
    Male2411.31 (reference)7813.81 (reference)
Age, y
    0–32813.51 (reference)9544.71 (reference)
    4–6115.50.40.2–0.83221.70.70.6–0.8
    7–931.70.10.0–0.41210.70.50.4–0.6
    10–1400.00540.40.30.2–0.4
Geographical area
    North3112.51.80.7–4.28213.30.70.6–0.8
    Center67.01 (reference)4014.91 (reference)
    South56.91.00.3–3.22293.20.70.5–0.8
Concomitant drug use*
    Any type of antibiotic149.10.80.4–1.65723.81.00.9–1.1
        Penicillins59.91.00.4–2.22054.21.11.0–1.3
        Cephalosporins57.00.60.2–1.62663.91.00.9–1.2
        Sulfonamides00.0021.2NA
        Macrolides411.81.20.4–3.21263.81.00.8–1.2
    Antimycotic agents00.002017.25.53.5–8.7
    Antimycobacterial agents00.0014.7NA
    Antiviral agents00.006129.99.27.1–12.0
Indications
    Otitis media25.31 (reference)942.51 (reference)
    Upper respiratory tract infections126.81.30.3–5.84872.81.10.9–1.4
    Gastrointestinal infections114.52.80.3–30.4192.81.10.7–1.8
    Bronchitis/pneumonia114.12.70.2–29.6223.21.30.8–2
    Other infectious disease513.52.60.5–13.31093.01.20.9–1.6
    Exanthematic diseases000103.41.30.7–2.6
    Trauma000101.70.70.4–1.3
    Allergy0001010.44.12.2–7.9
    Dermatological disease00012.10.90.1–6.1
    General check-up14.50.90.1–9.4492.20.90.6–1.2
    Symptoms without clear origin38.31.60.3–9.4802.20.90.7–1.2
    Other18.81.70.2–18.4212.10.80.5–1.3
    Not coded/unknown1626.451.2–21.85398.83.52.8–4.3
Total4210.314513.7
  • * Reference is the group of nonusers of the specific drug.