TABLE 5.

Cephalosporin Allergy Among Penicillin-Allergic Patients3,74

Cephalosporin and History of Penicillin Allergy (n)Adverse Reactions, No. (%)Type of Reaction (No.)P Value*
Cephaloridine
    No (3471)86 (2.6)No data
    Yes (109)14 (13.0)Rash (11), urticaria (6), fever (1)<.001
Cephalothin
    No (1045)21 (2.0)Anaphylaxis (2), rash or urticaria (14), unspecified (5).016
    Yes (138)8 (5.8)Anaphylaxis (2), rash or urticaria (5), unspecified (1)
Cephalexin
    No (7819)87 (1.1)Rash (37), urticaria (12), miscellaneous (12)<.0001
    Yes (291)19 (6.5)§Rash (8), urticaria (1), miscellaneous (2)
Cefazolin
    No (1369)8 (0.6)No data.08
    Yes (74)3 (4.0)No data
Cefamandole
    No (1303)83 (6.4)No data.017
    Yes (89)13 (14.6)No data
Overall cephalosporins
    No (15 007)285 (1.9).0001
    Yes (701)57 (8.1)
  • * Comparing those with and without a history of penicillin allergy.

  • In ref 3, there were 18 patients in this group; in ref 74, there were 14 patients in this group.

  • In ref 3, there were 61 patients in this group; in ref 74, there were 87 patients in this group.

  • § In ref 3, there were 11 patients in this group; in ref 74, there were 19 patients in this group.