TABLE 3.

Proportions of Patients With “Allergic Reactions” to Cephalosporins, Stratified According to Cephalosporin Generation, Penicillin Allergy History, and Penicillin Skin Test Results

Cephalosporin GenerationPenicillin Allergy History But No Skin Testing, No. (%)P ValuePenicillin Allergy Skin Test Confirmed, No. (%)P Value
YesNoYesNo
First
    Reported proportion83/1043 (7.9)*458/3288 (1.4)<.000115/138 (10.9)2/63 (3.2)§.12
    Attributable proportion21/1088 (1.9)458/32 885 (1.4).184/138 (2.9)2/63 (3.2).73
Second11/585 (1.9)112/675 (1.7).825/269 (1.9)6/497 (1.2).69
Third5/772 (0.6)#77/5452 (1.4)**.122/259 (0.8)††7/497 (1.4).68
Unspecified2/129 (1.6)‡‡6/341 (1.8)§§.81
  • Excluding anaphylaxis case reports presented in Table 9.

  • * From refs 66, 72, 74, and 78 to 81.

  • From refs 4, 72, and 78 to 81.

  • From refs 4, 7, 67, 69, 70, 82, and 83.

  • § From refs 4 and 44.

  • Data included from author's unpublished prospective case series with history and skin-testing techniques, as described in ref 38.

  • From refs 67, 69, and 70.

  • # From refs 12, 18, and 58.

  • ** From ref 12.

  • †† From refs 70 and 82.

  • ‡‡ From refs 5, 43, 45, 71, and 84.

  • §§ From refs 43, 71, and 84.