TABLE 1

Quantitative Correlates of Protection After Vaccination

VaccineTestCorrelate of Protection
Hib conjugateELISA0.15 μg/mL
PneumococcusELISA; opsonophagocytosis0.20–0.35 μg/mL (for children); 1/8 dilution MeningococcusBactericidal1:8 human complement
1:16 rabbit complement
DiphtheriaToxin neutralization0.01–0.10 IU/mL
TetanusToxin neutralization0.01 IU/mL
Acellular pertussisELISAUnknown
PolioMicroneutralization1/4–1/8 dilution
MeaslesMicroneutralization120 mIU/mL
MumpsELISA2 ELU/mL
RubellaImmunoprecipitation10–15 mIU/mL
VaricellaSN; gpELISA≥1/64 dilution; ≥5 IU/mL
Hepatitis BELISA10 mIU/mL
Hepatitis AELISA10 mIU/mL
RotavirusELISA IgA; microneutralizationUnknown
HPVELISA; microneutralizationUnknown
  • ELISA indicates enzyme-linked immunosorbent assay; ELU, ELISA Units; SN, serum neutralization; gpELISA, glyco protein ELISA enzyme-linked immunosorbent assay; Ig, immunoglobulin.

  • Adapted from Plotkin SA. Clin Infect Dis. 2008;47(3):401–408.