TABLE 1

Age and Primary Symptom, Sign, or Indication (Associated Condition) Leading to Intestinal Biopsy to Diagnose Celiac Disease, According to Group

Pretesting (N = 36)Testing (N = 199)P
Age at diagnosis, median (95% CI), y2 (2–4)9 (8–10)<.001
Presentation, n (%)
    Classic24 (67)39 (19)<.001
    Atypical gastrointestinal7 (19)76 (38).0481
        Abdominal pain plus othera534
        Abdominal pain onlyb018
        Endoscopy for other reasonb,c08
        Chronic diarrhead17
        Constipationb05
        Vomiting12
        Food allergyb01
        Abdominal distentionb01
    Extraintestinal5 (14)29 (15).914
        Failure to thrivee213
        Iron deficiency, with or without anemia26
        Short statureb06
        Dermatitis herpetiformisb02
        Elevated transaminase levelsb01
        Dental enamel defectsb01
        Hypoalbuminemia10
    Silent0 (0)55 (28)<.001
        Family historyb035
        Type 1 diabetes mellitusb014
        Trisomy 21b05
        Hypothyroidismb01
    Total36 (100)199 (100)
  • a With other symptoms or associated conditions.

  • b Previously unrecognized clinical presentation.

  • c Gastroesophageal reflux, n = 3; dysphagia, n = 2; bloody diarrhea, n = 2; hypereosinophilic syndrome, n = 1.

  • d Without failure to thrive or weight loss.

  • e Without diarrhea.