TABLE 2

Pace of Pathogenesis, Memory Mechanism, and Need for Boosters

DiseasePace of PathogenesisLive (Attenuated) vs InertBooster Needed
DiphtheriaFastInertYes
TetanusSlowInertYesa
PertussisFastInertYes
PolioSlowInertNo
MeaslesSlowLive (attenuated)No
MumpsSlowLive (attenuated)No
RubellaSlowLive (attenuated)No
HibFastInertYes
Hepatitis BSlowInertNo
VaricellaSlowLive (attenuated)?
PneumococcalFastInertYes
MeningococcalFastInertYes
Hepatitis ASlowInertNo
RotavirusFastLive (reassortant)No
HPVUnknownInert?
  • a The booster can be given after exposure, because the pace of pathogenesis is slow.