Other Risk Factors for Severe Hyperbilirubinemia to be Considered with the Gestational Age and the Pre-discharge TSB or TcB level (see Figure 3)

Exclusive breastfeeding, particularly if nursing is not going well and/or weight loss is excessive (>8 –10%)
Isoimmune or other hemolytic disease (eg, G6PD deficiency, hereditary spherocytosis)
Previous sibling with jaundice
Cephalohematoma or significant bruising
East Asian race
  • The gestational age and the predischarge TSB or TcB level are the most important factors that help to predict the risk of hyperbilirubinemia. The risk increases with each decreasing week of gestation from 42–35 weeks (see Figure 3)