TABLE 2

Selected Prenatal and Postnatal Factors Associated With CLD and MDI or PDI at 24 Months' Postterm Equivalent

Postnatal FactorsCLD, %MDI, %PDI, %N
<5555–69<5555–69
Marital status
    Single4716141216375
    Not single5089816540
Antenatal corticosteroida
    Complete4712111215588
    Incomplete54912617234
    None4811941593
Cesarean delivery
    Yes491010915611
    No4913121016304
Initiator of preterm delivery
    Preterm labor46911818411
    Preterm, prolonged rupture of membranes471491013201
    Preeclampsia581611189120
    Abruption55511216100
    Cervical insufficiency441410151548
    Fetal indicationb63172092035
Gestational age, wk
    2378131392832
    24771610914130
    256111131118184
    26441281014250
    2732812814319
Birth weight z score
    Less than −17117131618174
    −1 to 0521111716342
    0 or higher37910914399
SNAP-II
    <203899814489
    20–295713131018222
    ≥306916121219187
Pao2 week 1
    <42 (lowest quartile)711913181379
    ≥426313121118321
    Missing37910714515
Pao2 week 2
    <41 (lowest quartile)732512242051
    ≥416615151223165
    Missing43910814699
Early bacteremia, week 1
    None479101016532
    Presumed521312514325
    Definite51191692357
Late bacteremia, week 2–4
    None44910814549
    Presumed589121216139
    Definite5518131121224
Maximum n4501039986143915
  • CLD included infants with and without MV (CMV or high-frequency ventilation).

  • a A course of antenatal corticosteroids given to enhance fetal lung maturation was considered complete if the mother received 2 doses of betamethasone 24 hours apart or 4 doses of dexamethasone at 12-hour intervals and delivered at least 48 hours after the first dose.

  • b Fetal indication includes nonreassuring fetal assessments, oligohydramnios, Doppler abnormalities of umbilical cord blood flow, and severe intrauterine growth restriction.