TABLE 3

Adjusted IRRs (95% CIs) of ASDs After Family History of AD

ADPrevious AD
Parent or Sibling, IRR (95% CI)aMother Only, IRR (95% CI)bFather Only, IRR (95% CI)c
All ADs combined1.04 (0.91–1.19)1.02 (0.85–1.22)1.04 (0.83–1.29)
Endocrine AD0.92 (0.72–1.17)0.71 (0.48–1.01)1.33 (0.94–1.83)
    Thyrotoxicosis0.61 (0.36–0.96)d0.58 (0.32–0.95)dNA
    Autoimmune thyroiditis1.21 (0.43–2.60)NANA
    T1D1.04 (0.77–1.38)0.93 (0.52–1.51)1.32 (0.90–1.85)
Connective tissue AD1.20 (0.89–1.58)1.56 (1.08–2.17)d0.59 (0.25–1.13)
    RA1.32 (0.88–1.90)1.70 (1.07–2.54)dNA
    Juvenile arthritis1.10 (0.55–1.92)NANA
Gastrointestinal AD1.05 (0.82–1.33)1.05 (0.74–1.43)1.02 (0.67–1.46)
    Celiac disease1.73 (0.87–3.04)2.97 (1.27–5.75)dNA
    Crohn disease0.96 (0.62–1.41)0.76 (0.38–1.33)1.09 (0.55–1.92)
    Ulcerative colitis1.02 (0.75–1.36)1.05 (0.68–1.53)0.99 (0.60–1.52)
Blood AD1.30 (0.59–2.43)NANA
Nervous system AD1.14 (0.72–1.71)1.35 (0.78–2.16)0.76 (0.27–1.64)
    Multiple sclerosis1.19 (0.70–1.88)1.36 (0.73–2.28)NA
Skin AD1.30 (0.91–1.80)1.44 (0.87–2.21)1.42 (0.82–2.27)
    Psoriasis vulgaris1.41 (0.96–1.98)1.55 (0.91–2.45)1.43 (0.78–2.35)
  • IRRs were adjusted for age and its interaction with gender, calendar year, place of birth, and ages of the mother and father at the time of the child's birth. NA indicates not applicable.

  • a Data show IRRs of ASDs associated with a history of the specific AD in a parents or sibling. People with no such history were chosen as reference category.

  • b Data show IRRs of ASDs associated with a history of the specific AD in the mother. People with no such history were chosen as a reference group. People with the ADs in both parents were not included.

  • c Data show IRRs of ASDs associated with a history of the specific AD in the father. People with no such history were chosen as a reference group. People with the AD in both parents were not included.

  • d P < .05.