TABLE 4

Medication and Treatment Associated With CLD and MDIs and PDIs at 24 Months' Postterm Equivalent

Medications and TherapiesCLD, %MDI, %PDI, %N
<5555–69<5555–69
Surfactant, first week
    Yes5311111016809
    No241111712106
Methylxanthine
    Yes431111915787
    No8515121122128
Hydrocortisone
    Yes67158181685
    No471111916830
Dexamethasone
    Yes7142182524
    No491111915821
Analgesics
    Yes5612101115579
    No371012717336
Sedative
    Yes571815820200
    No4710101014716
PDA treatmenta
    Ligation6916101121127
    Indomethacin5310121115349
    Neither461113810130
PDA treatmentb
    Yes5812121017544
    No371010814371
Transfusionc
    Yes521211816842
    No14811101172
  • CLD included infants with and without MV (CMV or high-frequency ventilation).

  • a Among those with a clinical or echocardiographic PDA diagnosis.

  • b Among all infants.

  • c Packed red blood cells during 3 or 4 separate weeks in the first postnatal month.