TABLE 1

Description of the Cohort and Crude Incidence and Crude IRRs for the Outcome of at Least 1 Seizure Diagnosis Plus at Least 1 AED Prescription by Demographic and Clinical Characteristics

N at RiskN With OutcomeIncidence per 1000 Person-yCrude IRR (95% CI)P
Total population496 63231530.79
 1995–2000164 62314550.74Reference
 2001–2006177 16711140.791.07 (0.99 to 1.16).076
 2007–2011154 8425840.941.27 (1.16 to 1.41)<.0001
Maternal age, y
 <25107 6717330.82Reference
 ≥25388 96124200.780.95 (0.87 to 1.03).2143
Sex
 Female242 87914030.72Reference
 Male253 75317500.861.2 (1.12 to 1.29)<.0001
Race and/or ethnicity
 White210 28014010.81Reference
 Asian American92 9975000.680.84 (0.76 to 0.93).0009
 African American38 7973711.101.36 (1.21 to 1.52)<.0001
 Hispanic119 7667330.770.95 (0.87 to 1.04).27
 Other34 7921480.600.74 (0.62 to 0.88).0003
Down syndrome511153.774.8 (2.68 to 7.93)<.0001
Chromosomal anomaly other than trisomy 216479818.924.67 (19.96 to 30.17)<.0001
Congenital anomaly98141602.473.25 (2.76 to 3.82)<.0001
Gestational age, wk
 <3858 5564721.051.38 (1.25 to 1.52)<.0001
 ≥38438 07626810.76Reference
Birth wt, g
 <250016 6502001.532.01 (1.73 to 2.32)<.0001
 ≥2500479 98229530.76Reference
Size for gestational age
 Small (<10th percentile)49 1223971.001.31 (1.17 to 1.45)<.0001
 Appropriate or large447 51027560.76Reference
Cesarean delivery
 No385 89523840.75Reference
 Yes110 7377690.931.23 (1.13 to 1.34)<.0001
5-min Apgar <7
 No492 63531090.78Reference
 Yes3997441.421.81 (1.31 to 2.44).0003
DAT result
 Not done310 50420070.740.83 (0.77 to 0.89)<.0001
 Negative175 62810780.89Reference
 Positive10 500680.890.99 (0.77 to 1.27).98
Conjugated bilirubin ≥1.0 mg/dL2116332.072.64 (1.82 to 3.72)<.0001
Maximum TSB, mg/dL
 <10102 4855000.85Reference
 10–14.979 5334960.911.07 (0.94 to 1.21).28
 15–19.961 4724010.931.1 (0.96 to 1.26).16
 20–24.98022781.151.35 (1.05 to 1.72).016
 Not done245 12016780.710.84 (0.76 to 0.93).0008
Any phototherapy
 No458 94928700.76Reference
 Yes37 6832831.241.63 (1.44 to 1.85)<.0001
Phototherapy dose
 None459 94928700.76Reference
 Home only5027150.590.77 (0.43 to 1.27).32
 1 admission31 8932631.331.74 (1.53 to 1.98)<.0001
 ≥2 admissions76351.301.71 (0.55 to 4).25
Diagnoses made at <60 d
 Meningitis36741.251.59 (0.43 to 4.08).36
 Birth asphyxia/hypoxic ischemic encephalopathy1182131.221.55 (0.83 to 2.66).13
 Intracranial hemorrhage17375.286.71 (2.69 to 13.84).0001
  • IRR, incidence rate ratio; —, not applicable.