TABLE 3.

Unadjusted Mean TLC Neuropsychological Outcome Scores by Treatment Arm*

VariableSuccimer GroupPlacebo GroupSuccimer-Placebo
NMeanSDNMeanSDP ValueDifference95% CI
Cognition (WISC-III, NEPSY, WLPB-R)
 Full-Scale IQ32386.913.232186.513.40.670.4(−1.6 to 2.5)
 Attention/Executive Functions30086.316.529388.117.60.20−1.8(−4.5 to 1.0)
 Reading30294.818.429893.918.50.531.0(−2.0 to 3.9)
Behavior (BASC)*
 Adaptive Skills (Teacher)25946.69.727246.09.20.450.6(−1.0 to 2.2)
 Externalizing Problems (Teacher)26655.213.927455.312.10.93−0.1(−2.3 to 2.1)
 School Problems (Teacher)26755.912.427556.512.10.56−0.6(−2.7 to 1.5)
 Externalizing Problems (Parent)32558.816.532357.214.10.181.6(−0.8 to 4.0)
Learning and Memory (CVLT-C)*
 List A Memory32543.411.332043.911.80.57−0.5(−2.3 to 1.3)
 List A Learning Slope325−0.41.1320−0.41.20.870.0(−0.2 to 0.2)
Attention (CPT)*
 d Prime28755.29.828556.39.90.16−1.2(−2.8 to 0.5)
Neuromotor (CPT, NESS)*
 Hit Reaction Time28742.713.128542.612.80.870.2(−2.0 to 2.3)
Sequential Movements Time2861.01.32790.91.30.530.1(−0.1 to 0.3)
  • WISC-III indicate Wechlser Intelligence Scales for Children-III; WLPB-R, Woodcock Language Proficiency Battery–Revised; BASC, Behavioral Assessment System for Children; CVLTC, California Verbal Learning Test for Children; CPT, Conners' Continuous Performance Test; NESS, Neurological Examination for Soft Signs.

  • * Higher scores are optimal for the variables Full-Scale IQ, Attention/Executive Functions, Reading, Adaptive Skills, List A Memory, List A Learning Slope, and Hit Reaction Time. Lower scores are optimal for Externalizing Problems, School Problems, d Prime, and Sequential Movements Time.