Multivariate Logistic Regression Analysis of Antibiotic Duration and NEC or Death Among Infants Intubated for the First 7 Postnatal Days

OutcomeDuration of Initial Empirical Antibiotic Treatment (Odds per Day)Prolonged Initial Empirical Antibiotic Treatment
OR (95% CI)POR (95% CI)P
NEC or death (total, N = 2128; with outcome, n = 635)1.04 (1.01–1.07).011.41 (1.14–1.75)<.01
NEC (total, N = 2141; with outcome, n = 238)1.09 (1.05–1.13)<.0011.50 (1.11–2.02)<.01
Death (total, N = 2127; with outcome, n = 509)1.13 (1.05–1.22)<.011.42 (1.13–1.80)<.01
  • Infants who were intubated continuously until death but who died before day 7 (n = 52) were included in this subgroup. ORs were adjusted for study center, gestational age, small-for-gestational age status, gender, black race, 5-minute Apgar score of <5, rupture of membranes for >24 hours, outborn, prenatal steroid treatment, intrapartum antibiotic treatment, maternal hypertension, maternal hemorrhage, and multiple birth. The total numbers of infants shown represent the numbers of infants in this subset with nonmissing outcome and covariate data.