TABLE 2.

Demographic and Clinical Characteristics of 154 Hospitalized Children With Community-Acquired LRIs Associated With Bacterial, Viral, or Unknown Pathogens

CharacteristicsType of Lower Respiratory PathogensP Value
Typical BacteriaaM pneumoniae or C pneumoniaebVirusescMixed Bacteria/VirusesdUnknown
No. of patients, %40 (26)17 (11)29 (19)36 (23)32 (21)
Age, mo (range)e39.5 (2.3–209)60.2 (9–155)f18.5 (2.2–194)fg27.6 (2–134)41.4 (4–158)g.015
Age <5 y, %7047767863.17
Gender, % male73f476944f72.04
Duration of symptoms before admission, dayse6.03.57.05.04.0.41
Antibiotic therapy during preceding 2 weeks, %3324554438.20
Temperature on admission, °Ch39.439.139.039.239.1.46
Maximum temperature ≤72 hours after admission, °Ch38.4fg37.5gi37.6fj38.5ij37.9.001
Wheeze, %13f4141fg14g31.01
Lobar or segmental consolidation ± effusion, %7553456953.06
Pleural effusion, %50fgj6f10g3919j.0002
WBC count, × 109/Le16.112.314.515.614.4.76
Band forms, %e6.51.5f1.0g11.5fg3.0.038
Band forms (proportion >10%)398f2756fg19g.006
S pneumoniae NP colonization, %2012352222.48
Procalcitonin, ng/mLe2.4f0.7fg0.6j2.6gj1.3.014
Procalcitonin, proportion ≥0.75 ng/mL68f4132fgj66g67j.012
Paired serum available, %7882799469.08
Macrolide/azalide included in regimen, %818171122.44
Duration of oxygen therapy, dayse1.21.01.82.01.8.28
Duration of hospitalization, % >5 daysek62fg24f3159j23gj.001
No. ventilated/died/readmitted within 30 days of discharge1/0/01/0/03/0/13/2/22/0/1ND
  • NP indicates nasopharyngeal; ND, not done (sparse data).

  • a Typical respiratory pathogens included S pneumoniae, S pyogenes, S milleri, S aureus, and M tuberculosis. This category included children with mixed typical bacterial infections as well as 3 patients acutely coinfected with M pneumoniae (n = 2) or C pneumoniae (n = 1).

  • b Eleven children had M pneumoniae infections only, and 6 had C pneumoniae infections only. Ten additional children with M pneumoniae were coinfected with other bacteria or viruses, and 8 additional children with C pneumonaie were coinfected with other bacteria or viruses. Patients infected with atypical bacterial pathogens who had concurrent typical bacterial infections were classified as “typical bacteria,” and those coinfected with viruses were categorized as “mixed bacterial/viral.” Median age and range for all M pneumoniae cases (n = 21) was 60 months (6–148 months) and for all C pneumoniae cases (n = 14) was 35 months (7–155 months).

  • c The viral category included children with single or multiple concurrent viral pathogens.

  • d The mixed bacterial/viral category included patients with combinations of typical or atypical respiratory bacteria and viral pathogens.

  • e The median value was used.

  • f Significant differences were observed between each pair of values.

  • g Significant differences were observed between each pair of values.

  • h The mean value was used.

  • i Significant differences were observed between each pair of values.

  • j Significant differences were observed between each pair of values.

  • k Four patients with prolonged admissions for social indications were omitted.