National Institutes of Health Diagnostic Criteria for NF1

Two or more of the following clinical features signify the presence of NF1 in a patient
    Six or more café-au-lait macules (>0.5 cm at largest diameter in prepubertal individuals or >1.5 cm in individuals past puberty)
    Axillary freckling or freckling in inguinal regions
    Two or more neurofibromas of any type or ≥1 plexiform neurofibroma
    Two or more Lisch nodules (iris hamartomas)
    A distinctive osseous lesion
    A first-degree relative with NF1 diagnosed by using the above-listed criteria
  • Data are from the National Institutes of Health.5