Diagnostic Criteria for B henselae Infection

Three of 4 of the following:
  1. Cat or flea contact regardless of presence of inoculation site

  2. Negative serology for other causes of adenopathy, sterile pus aspirated from a node, a positive PCR assay, and/or liver/spleen lesions seen on CT scan

  3. Positive enzyme immunoassay or IFA assay with a titer ratio of ≥1:64

  4. Biopsy showing granulomatous inflammation consistent with CSD or a positive Warthin-Starry silver stain

  • Diagnostic criteria are adapted from Margileth.120