TABLE 4

ADEs Unique to Each System

ReasonTotal (%)ADEs/1000 Patient-Days
SRSa
    Allergies5 (5.4)0.10
        Known1 (1.1)0.02
        Unknown4 (4.3)0.08
    IV infiltrates25 (26.9)0.49
        Medication use process23 (24.7)0.45
        Administration: dose rate12 (12.9)0.24
        Administration: drug2 (2.2)0.04
        Administration: route2 (2.2)0.04
        Miscellaneous IV issues3 (3.2)0.06
        Ordering3 (3.2)0.06
        Transcription1 (1.1)0.02
    Omission of drug15 (16.1)0.29
    Pump malfunction4 (4.3)0.08
ADE-Sb
    Activated charcoal1 (1.3)0.02
    ALT ≤20% >450 and on isoniazid, phenytoin, cyclosporine, methotrexate, or warfarin over the past 7 d3 (3.9)0.06
    Digibind IV given1 (1.3)0.02
    Hydrocortisone given3 (3.9)0.06
    Theophylline >20 μg/mL1 (1.3)0.02
    Oxcarbazepine and Na <1301 (1.3)0.02
    Quinidine >5 μg/mL1 (1.3)0.02
  • Cr indicates serum creatinine; ALT, alanine aminotransferase liver enzyme level.

  • a Severity score was ≥3.

  • b Severity score was ≥3 and causality score was ≥5.