TABLE 3

Detection of ADE Categories Shared by Each System

SRSaADE-SbPc
ReasonTotal (%)ADEs/1000 Patient-DaysReasonTotal (%)ADEs/1000 Patient-Days
Anticoagulants2 (2.2)0.04Anticoagulants6 (7.7)0.13.17
    Heparin given and 2 PTT >1005 (6.4)0.10
    Vitamin K and INR >31 (1.3)0.02
C difficile infection2 (2.2)0.04C difficile infection13 (16.7)0.33.003c
    Metronidazole, vancomycin and C difficile toxicity assay5 (6.4)0.10
    Oral metronidazole8 (10.3)0.17
Hyperkalemia3 (3.2)0.06Hyperkalemia8 (10.3)0.33.13
    Polystyrene7 (9.0)0.15
    Potassium >6.51 (1.3)0.02
Hypoglycemia3 (3.2)0.06Hypoglycemia9 (11.5)0.19
    Blood gas glucose test <505 (6.4)0.10.08
    Dextrose 50% given4 (5.1)0.08
Narcotics and benzodiazepines5 (5.4)0.10Narcotics and benzodiazepines15 (19.3)0.31.02
    Flumazenil IV given1 (1.3)0.02
    Meperidine and Cr >1.51 (1.3)0.02
    Naloxone IV given13 (16.7)0.27
Nephrotoxins6 (6.5)0.12Nephrotoxins14 (20.7)0.29.07
    Amikacin >5.0 μg/mL Pre1 (1.3)0.02
    Gentamicin >2 μg/mL Pre8 (10.3)0.17
    Tacrolimus result >201 (1.3)0.02
    Tobramycin >2 μg/mL Pre2 (2.6)0.04
    Vancomycin >20 μg/mL Pre2 (2.6)0.04
    Vancomycin and Cr >1.5 in 1 d and Cr rise >0.52 (2.6)0.04
  • Cr indicates serum creatinine.

  • a Severity score was ≥3.

  • b Severity score was ≥3 and causality score was ≥5.

  • c Data remain statistically significant after Bonferroni correction for multiple testing, (P = .018).