TABLE 2

Infant Demographic Features and Risk Factors Before Development of IC in 2000–2001 and 2002–2006

2000–2001 (N = 19)2002–2006 (N = 22)P
Demographic features
    Gestation, median (range), wk25 (22–36)28 (23–38.7).03
    BW, median (range), g650 (455–2199)1105 (550–3058).004
    Age at onset, median (range), d12 (6–64)23.5 (4–133).17
    Male, n (%)7 (37)9 (41).99
Maternal characteristics
    Multiple gestation, n (%)7 (37)3 (14).14
    Prenatal steroid treatment, n (%)13 (68)14 (64).70
    Prenatal antibiotic treatment, n (%)17 (89)15 (68).40
    Vaginal delivery, n (%)9 (42)10 (45).48
Risk factors for infection
    History of antibiotic use
        Vancomycin, n (%)8 (42)14 (64).217
        Third-generation cephalosporin, n (%)6 (32)5 (23).725
        Duration of antibiotic treatment, median (range), d10 (4–37)14 (3–50).967
    CVCs
        At time of infection, n (%)13 (68)16 (73).99
        No. of CVCs, median (range)3 (1–3)3 (1–5).765
        Duration of use, median (range), d10 (5–45)17 (4–133).13
    TPN
        At time of infection, n (%)17 (89)16 (73).249
        Duration, median (range), d8 (3–36)19.5 (0–86).096
    Steroids, n (%)13 (68)9 (41).118
    H2 receptor blockers, n (%)3 (16)15 (68).001
    Previous endotracheal intubation, n (%)19 (100)21 (95).99
    Necrotizing enterocolitis, n (%)1 (5)6 (27).10
    Known to be colonized, n (%)4 (21)4 (18).99
  • The Mann-Whitney U test was used for median values.