TABLE 3.

Risk Factors for Development of CLD in Preterm VLBW Infants

VariableUnivariate AnalysisMultivariate Analysis
Oxygen Dependency at 28 DaysOxygen Dependency at 36 WeeksOxygen Dependency at 28 DaysOxygen Dependency at 36 Weeks
OR (95% CI)OR (95% CI)AOR (95% CI)AOR (95% CI)
Birth weight <750 g7.38 (2.89, 18.9)*6.67 (1.48, 30.1)*5.03 (1.29, 19.7)*NS
Gestational age <26 wk13.3 (4.89, 35.9)*7.06 (1.56, 31.9)*5.58 (1.48, 21)*NS
Male gender2.83 (1.16, 6.89)*1.73 (0.39, 7.59)4.03 (1.08, 15.1)*NS
Patent ductus arteriosus17.9 (5.01, 64)*9.23 (1.10, 77.6)*14.1 (2.97, 67)*NS
Inborn0.27 (.08, .93)*0.24 (.04, 1.36)NSNS
Vaginal delivery1.12 (0.45, 2.79)2.55 (0.60, 10.8)NSNS
Antenatal steroids3.66 (0.80, 16.8)0.67 (0.13, 3.55)NSNS
Any episode of sepsis3.03 (1.22, 7.52)*4.11 (0.88, 19.1)NS10.3 (1.53, 69)*
Surfactant administration3.24 (1.13, 9.26)*24.5 (4.44, 135)*NSNS
Persistently positive U urealyticum colonization10.0 (3.30, 30.3)*24.5 (4.44, 135)*5.33 (1.05, 27)*33.6 (4.78, 237)*
  • NS indicates not significant.

  • * P value <.05 when 95% CI for OR excludes 1.