TABLE 2.

Patient Characteristics by Ureaplasma urealyticum Colonization Pattern in Preterm VLBW Infants

CharacteristicsPersistently Positive N = 18Early Transient N = 14Late Acquisition N = 8Negative N = 85P Values*
Continuous VariablesMean ± Standard Error, RangeMean ± Standard Error, RangeMean ± Standard Error, RangeMean ± Standard Error, Range
Birth weight (g)755 ± 9.01192 ± 19.91068 ± 25.11028 ± 3.6<.001
(530–1170)(705–1360)(900–1580)(510–1350)
Gestational age (wk)25.2 ± 0.1029.4 ± 0.1528.0 ± 0.2828.2 ± 0.03<.001
(23–29)(25–32)(25–32)(23–35)
Categorical VariablesNumber (%) OR (95% CI)Number (%) OR (95% CI)Number (%) OR (% CI)Number (%) Reference
Birth weight distribution (g)10 (56)1 (7)0 (0)22 (26).004
 <7503.58 (1.31, 9.8)0.22 (0.01, 3.7)
7 (39)2 (14)1 (12)18 (21).33
 750–9992.37 (0.74, 7.6)0.62 (0.08, 4.7)0.53 (0.03, 8.9)
1 (6)11 (79)7 (88)45 (53)<.001
 ≥10000.05 (0, 0.86)3.26 (1.28, 8.3)6.22 (2.01, 19.3)
Male gender10 (56)2 (14)4 (50)48 (56).03
0.96 (0.4, 2.6)0.13 (0.02, 0.96)0.77 (0.2, 3.3)
Vaginal delivery10 (56)4 (29)3 (37.5)20 (24).06
4.1 (1.5, 11.2)1.3 (0.3.5.7)2.0 (0.4, 10.4)
Inborn12 (67)14 (100)6 (75)79 (93).003
0.15 (0.05, 0.48)2.1 (0.7, 6.5)0.23 (0.06, 0.93)
Multiple birth5 (28)7 (50)1 (12.5)24 (28).26
0.98 (0.3, 3.7)2.5 (0.8, 8.0)0.36 (0.02, 6.0)
Resuscitation at delivery15 (83)4 (29)1 (12.5)26 (31)<.001
11.4 (4.8, 27)0.91 (0.2, 3.9)0.32 (.02, 5.4)
Apgar score <3, 1 min7 (39)2 (14)0 (0)14 (17).07
3.1 (0.9, 10)0.82 (0.1, 6.3)
Apgar score <6, 5 min6 (33)0 (0)1 (12.5)6 (7).006
6.4 (1.6, 26)1.8 (0.1, 33)
Conventional ventilation14 (78)3 (21)4 (50)33 (39).006
5.5 (2.3, 13)0.4 (0.08, 2.3)1.6 (0.4, 6.7)
High-frequency oscillatory ventilation0 (0)0 (0)1 (12.5)3 (4).34
3.9 (0.19, 79)
Surfactant administration4 (22)1 (7)2 (25)13 (15).55
1.6 (0.4, 7.0)0.4 (0.02, 7.1)1.8 (0.2, 14)
Pneumothorax2 (11)0 (0)0 (0)6 (7).52
1.7 (0.2, 13)
Late postnatal steroid use1 (6)0 (0)0 (0)1 (1).56
5.0 (0.2, 150)
Any intraventricular hemorrhage2 (11)0 (0)2 (25)14 (17).23
1.5 (0.3, 6.5)1.7 (0.2, 13)
Necrotizing enterocolitis2 (11)1 (7)3 (38)*6 (7).08
1.6 (0.2, 13)0.97 (0.05, 18)7.6 (1.3, 46)
Any episode of sepsis5 (28)4 (29)4 (50)18 (21).30
1.4 (0.4, 5.4)1.5 (0.3, 6.5)3.7 (0.8, 16)
Retinopathy of prematurity5 (28)2 (14)1 (12.5)11 (13).50
2.4 (0.6, 9.7)1.1 (0.15, 8.9)0.9 (0.05, 15)
Patent ductus arteriosus12 (67)4 (29)4 (50)37 (44).22
2.5 (1.0, 6.2)0.6 (0.1, 2.4)1.2 (0.3, 5.3)
Death beyond 2 weeks of life1 (6)0 (0)0 (0)4 (5)1.0
0.9 (0.05, 17)
  • * P value based on global χ2 test or Fisher exact test on 3 degrees of freedom, or on 1-way analysis of variance F test (for continuous variables).

  • P < .05 by post-hoc Dunnett test, using negative U urealyticum colonization status as the reference level (control).

  • P value <.05 when 95% CI for OR excludes 1.

  • § Delivery room resuscitation defined as need for positive pressure ventilation with bag and mask or intubation with positive pressure ventilation. All other infants were placed immediately onto nasal continuous positive airway pressure.

  • Use of conventional ventilation defined as being required at any time during hospitalization. Sepsis defined as a symptomatic infant prompting a work up and yielding a positive blood culture. The organisms identified from blood cultures included: 1 Escherichia coli, 1 group D Streptococcus, 1 Group B Streptococcus, 15 Staphylococcus epidermidis, 5 Staphylococcus aureus, 3 Staphylococcus hominis, 2 Klebsiella pneumoniae, 3 Enterobacter cloacae, 1 Acinetobacter, and 4 Candida. Retinopathy of prematurity defined as stage 1 or greater during screening examination at any age during hospitalization. Patent ductus arteriosus defined as a symptomatic infant with a murmur and/or bounding pulses with echocardiographic confirmation.