TABLE 1.

Outcome Data and Colonization Patterns of Ureaplasma urealyticum in Preterm VLBW Infants

Outcome*Persistently Positive N = 18 n/N (%) OR (95% CI)Early Transient N = 14 n/N (%) OR (95% CI)Late Acquisition N = 8 n/N (%) OR (95% CI)Negative N = 85 n/N (%) ReferenceP Value
CLD at 28 d of age12/18 (67)1/14 (7)1/8 (12.5)15/80 (19)<.0001
8.7 (3.3, 23)0.33 (.02, 5.6)0.62 (.04, 10.5)
CLD at 36 wk postconceptional age6/18 (33)0/14 (0)1/8 (12.5)1/78 (1.2)<.0001
38.5 (4.0, 74)11.0 (0.4, 330)
Radiographic diagnosis of CLD9/17 (53)0/14 (0)2/8 (25)13/84 (15).002
6.1 (2.1, 8.4)1.8 (0.2, 14.1)
Mean length of stay d ± standard78.8 ± 1.62§49.5 ± 2.6968.4 ± 4.4350.5 ± 0.43.004
error (range)(40–108)(16–108)(28–110)(19–121)
  • * One infant in persistently positive category and 4 infants in negative group expired beyond 2 weeks of life. Of the infants in the negative group who had recovered from acute lung disease, 3 infants died and 2 were transferred by 28 days of age, and 2 additional infants were transferred by 36 weeks’ postconceptional age.

  • P value based on global χ2 test or Fisher exact test on 3 degrees of freedom, or on 1-way analysis of variance F test (for length of stay).

  • P value <.05 when 95% CI for OR excludes 1.

  • § P < .05 by post-hoc Dunnett test, using negative U urealyticum colonization status as the reference level (control).

  • Radiographs were obtained within a 7-day window from the CLD definitions (day of life 28 and 36 weeks’ postconceptional age). The radiographs were read independently by pediatric radiologists who were blinded to the U urealyticum colonization patterns. Radiographic results were not available for 1 infant in the persistently positive and 1 infant in the negative categories.

  • Infants transferred to other institutions were not included in the analysis.