TABLE 3.

Comparison of 3 Pediatric ADEM Studies

ParametersPresentDale7Hynson8
Demographics
 Study typeRetrospectiveRetrospectiveRetrospective
 Geographical areaUSAUKAustralia
 Number of patients182831
 Age (y; range, mean)2–22, 83–15, 72–16, 6
 Seasonal clusteringYesYesNot known
 Preceding infection (%)727477
Clinical findings (%)
 Motor signs777123
 Altered consciousness456968
 Fever394352
 Cranial neuropathy235145
 Seizures171713
Laboratory findings (%)
 Leucocytosis396462
 CSF pleocytosis696462
 Elevated CSF protein556045
MRI findings (%)
 White matter lesions939190
 Thalamic lesions274132
 Periventricuar lesions604429
 Patients with follow-up MRI813025
 Normal follow-up MRI73725
Treatment and outcome (%)
 High-dose steroids218774
 Survival100100100
 Residual deficits174319
 Relapses02512