TABLE 6.

Infecting Pathogen Versus Death Rate, Late-Onset Sepsis Review: NICHD Neonatal Research Network, September 1, 1998, Through August 31, 2000

Organism*NDeath n (%)
All Gram-positive organisms905101 (11.2%)
Staphylococcus—coagulase-negative60655 (9.1%)
S aureus9917 (17.2%)
 Group B streptococcus327 (21.9%)
 All other streptococci657 (10.8%)
All Gram-negative organisms25793 (36.2%)
E coli5318 (34.0%)
Klebsiella6214 (22.6%)
Pseudomonas4332 (74.4%)
Enterobacter4111 (26.8%)
Serratia3914 (35.9%)
All fungal organisms15148 (31.8%)
C albicans8236 (43.9%)
Candida parapsilosis447 (15.9%)
  • * Organisms found on the last positive blood culture before death or discharge. Organism counts differ from those based on the first positive blood culture (Table 1) because of multiple sepsis episodes. Death rates are not shown for every organism found.

  • The ORs for death, with control for GA, study center, race, and sex were as follows: Gram-positive versus other infections (OR: 0.26 [0.19–0.35], P < .001); Gram-negative versus other infections (OR: 3.5 [2.5–4.9], P < .001); and fungi versus other infections (OR: 2.0 [1.3–3.0], P < .01).