TABLE 3.

Hospital Course: NICHD Neonatal Research Network, September 1, 1998, Through August 31, 2000

Neonatal VariableN*Neonates With Late-Onset Sepsis n (%)Adjusted OR (95% CI)P Value
Central venous catheter (d)
 057441042 (18%)1.0
 1–75628 (50%)3.0 (1.7–5.3)
 8–146031 (52%)3.8 (2.2–6.6)
 15–216431 (48%)3.3 (1.9–5.7)
 22+286177 (62%)6.1 (4.6–8.0)<.001
PICC (d)
 03367434 (13%)1.0
 1–738192 (24%)1.9 (1.4–2.5)
 8–14733143 (20%)1.5 (1.2–1.9)
 15–21592170 (29%)2.2 (1.8–2.8)
 22+1125472 (42%)3.7 (3.1–4.4)<.001
PAL (d)
 05310934 (18%)1.0
 1–7489183 (37%)2.3 (1.9–2.9)
 8–1423295 (41%)2.1 (1.5–2.8)
 15–2110754 (50%)2.7 (1.8–4.2)
 22+7345 (62%)3.9 (2.3–6.6)<.001
UAC (d)
 03067350 (11%)1.0
 1–71949507 (26%)1.7 (1.4–2.0)
 8–14889316 (36%)2.1 (1.7–2.6)
 15–2121196 (46%)2.8 (2.0–3.8)
 22+8041 (51%)2.9 (1.7–4.7)<.001
UVC (d)
 03735584 (16%)1.0
 1–71410354 (25%)1.6 (1.3–1.8)
 8–14808255 (32%)1.5 (1.2–1.9)
 15–2114760 (41%)2.1 (1.4–3.1)
 22+10158 (57%)4.1 (2.5–6.7)<.001
Hyperalimentation (d)
 0–7173452 (3%)1.0
 8–141463133 (9%)3.1 (2.2–4.3)
 15–21929206 (22%)7.9 (5.7–11.0)
 22+2011922 (46%)22.3 (16.2–30.5)<.001
Age at first feeding (d)
 0–74679794 (17%)1.0
 8–14850292 (34%)1.8 (1.5–2.2)
 15–2120088 (44%)2.6 (1.9–3.5)
 22+15487 (56%)4.0 (2.8–5.7)<.001
Age at full feedings (d)
 0–792129 (3%)1.0
 8–141814156 (9%)0.7 (0.5–0.8)
 15–211050217 (21%)1.4 (1.1–1.7)
 22–28658202 (31%)2.2 (1.7–2.8)
 29+1095528 (48%)4.3 (3.5–5.3)<.001
Days to regain birth weight
 0–7627106 (17%)1.0
 8–142628483 (18%)1.2 (1.0–1.5)
 15–211456356 (24%)1.3 (1.1–1.6)
 22+561223 (40%)1.8 (1.4–2.3)<.001
Mechanical ventilation (d)
 0–73708332 (9%)1.0
 8–14588184 (31%)2.8 (2.2–3.6)
 15–28732238 (33%)2.8 (2.2–3.6)
 29+1121559 (50%)5.6 (4.2–7.5)<.001
  • * Of 6215 infants, 1313 developed late onset sepsis. Total numbers may vary because of missing responses.

  • ORs (with 95% confidence intervals) and P values from logistic regression models fit to the late-onset sepsis indicator. Each variable above was included separately along with GA and study center.

  • Surgically placed central venous catheter.