TABLE 1

Potential Risk Factors Associated With IPS

Maternal factors/conditions
    Thrombotic disorders (see Table 2)
    Infertility and infertility treatment
    Preeclampsia
    Prolonged rupture of membrane (>24 h)
    Chorioamnionitis
    Maternal autoimmune conditions and autoantibodies (platelet alloantigen-1)
    Antiphospholipid syndrome
Fetal/neonatal disorders
    Mutations in procollagen IVa1
    Inherited thrombophilia
    Twin-to-twin transfusion syndrome
    Fetal/neonatal polycythemia
    Congenital heart disease
    Neonatal hypoglycemia (in preterm infants)
    Persistent fetal circulation and extracorporeal membrane oxygenation therapy
    Intrauterine growth restriction
    Fetal/neonatal infections and meningitis
Nonspecific factors
    Ethnicity and face (higher incidence in black infants compared with non-Hispanic white infants)
    Infant gender (higher incidence in boys)