Non-CD Children and Screening-Detected CD Children Reporting Symptoms Before Knowledge of Results of CD Serological Markers

SymptomaNon-CD (n = 6905)CD (n = 149)OR (95% CI)c
Tiredness117517.32617.61.0 (0.7–1.6)
Poor appetite3385.185.61.1 (0.5–2.2)
Nausea2303.442.70.8 (0.3–2.1)
Stomach ache4737.1107.00.9 (0.5–1.8)
Upset stomach3535.264.10.8 (0.3–1.7)
Abdominal gas3375.0106.81.4 (0.7–2.6)
Bloating1502.242.71.2 (0.4–3.3)
Hard stools4937.41711.61.7 (0.9–2.8)
Loose stools1572.442.81.2 (0.4–3.2)
Lactose intolerance3365.096.11.2 (0.6–2.4)
Any symptomd228333.15033.61.0 (0.7–1.4)
  • CD, celiac disease; CI, confidence interval; OR, odds ratio.

  • a Self-reported symptoms present often or always during the past 6 months.

  • b Internal nonresponses for non-CD children ranged from n = 126 to n = 285; for CD cases they ranged from n = 1 to n = 7. Proportions were calculated by using the total number of responses for each item as the denominator in the different groups. Thus, internal nonresponses were excluded for each item.

  • c OR of being a screening-detected CD case if symptom(s) present compared with if symptom(s) not present (with 95% CI) calculated by logistic regression, adjusted for gender.

  • d Having ≥1 of the symptom(s) listed above.