TABLE 1

Demographic Characteristics for Infant and Outcomes Cohort According to Outcomes Quartile (Based on FEV1 in 2003)

CharacteristicInfant CohortOutcomes Cohort
UQ (N = 755)LQ (N = 743)PUQ (N = 497)LQ (N = 340)P
Gender, n (%)
    Male398 (52.7)387 (52.1).807275 (55.3)173 (50.9).205
    Female357 (47.3)356 (47.9)222 (44.7)167 (49.1)
Age, mean ± SDa11.3 ± 10.80 mo11.6 ± 10.41 mo.5637.5 ± 1.51 y7.5 ± 1.47 y.833
Race, n (%)
    Non-Hispanic white686 (90.9)599 (80.6)<.0001458 (92.2)278 (81.8)<.0001
    Other69 (9.1)144 (19.4)39 (7.9)62 (18.2)
FEV1 % predicted, median107.1 ± 3.789.0 ± 6.5
Genotype, n (%)
    ΔF508 homozygote359 (47.5)268 (36.1)<.001210 (42.3)133 (39.1).311
    ΔF508 heterozygote250 (33.1)192 (25.8)194 (39.0)104 (30.6)
    Other60 (7.9)56 (7.5)
    Unknown86 (11.4)227 (30.6)
Diagnosis, n (%)b
    Clinical symptoms117 (15.5)193 (26.0)<.0001368 (74.0)316 (92.9)<.0001
    Family history142 (18.8)109 (14.7).03294 (18.9)49 (14.4).089
    Screening33 (4.4)9 (1.2).0002139 (28.0)17 (5.0)<.0001
    GenotypeNANA2 (0.4)3 (0.9).401c
    UnknownNANA5 (1.0)0 (0.0).084c
  • NA indicates not applicable.

  • a Age at enrollment for the infant cohort and age in 2003 for the outcomes cohort.

  • b Diagnosis data were collected from a larger number of categories in ESCF II than ESCF. The term “clinical symptoms” includes acute or persistent respiratory symptoms, edema/hypoproteinemia/hypoalbuminemia, failure to thrive/malnutrition, liver problems, meconium ileus/other intestinal obstructions, nasal polyps/sinus disease, rectal prolapse, and steatorrhea/abnormal stools/malabsorption. Screening includes neonatal screening and prenatal diagnosis.

  • c P value obtained from Fisher's exact test.